Teran Pumar OY, Lathia JD, Watson DC*, Bayik D*: 'Slicing' glioblastoma drivers with the Swiss cheese model. Trends Cancer. 2023. Aug 23:S2405-8033(23)00158-9

Lee J, Nicosia M, Hong ES, Silver DJ, Li C, Bayik D, Watson DC, Lauko A, Kay KE, Wang SZ, Johnson S, McGraw M, Grabowski M, Kish DD, Desai AB, Goodman WA, Cameron SJ, Okada H, Valujskikh A, Fairchild RL, Ahluwalia MS, Lathia J: Sex-biased T cell exhaustion drives differential immune responses in glioblastoma. Cancer Discov. 2023. Sep 6;13(9):2090-2105.

Alban T, Grabowski MM, Otvos B, Bayik D, Wang W, Zalavadia AH, Makarav V, Troike KM, McGraw M, Rabljenovic A, Lauko A, Neumann CK, Roversi G, Waite KA, Cioffi G, Patil N, Tran TT, McCortney K, Steffens A, Diaz-Montero CM, Brown JM, Egam KM, Horbinski C, Barnholtz-Sloan J, Rajappa P, Vogelbaum MA, Bucala R, Chan T+, Ahluwalia MS+, Lathia J+: The MIF SNP rs755622 is a germline determinant of tumor immune activation in glioblastoma. JCI Insight. 2023. doi: 10.1172/jci.insight.160024.

Watson DC*, Bayik D*, Storevik S*, Moreino S*, Sprowls SS, Han J, Augustsson MT, Lauko AJ, Sravya P, Rosland GV, Troike K, Tronstad KJ, Wang S, Sarnow K, Kay K, Lunavat T, Silver DJ, Dayal S, Joseph JV, Mulkearns-Hubert E, Ystaas LAR, Deshpande G, Guyon J, Zhou Y, Magaut CR, Seder J, Neises L, Williford SE, Meiser J, Scott AJ, Sajjakulnukit P, Mears JA, Bjerkvig R, Chakraborty A, Daubon T, Cheng F, Lyssiotis CA, Wahl DR, Hjelmeland AB, Hossain JA, Miletic H+, Lathia JD+: GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nature Cancer. 2023. May;4(5):648-664. * denotes co-first author [cover article, feature on the NIH Director’s Blog and National Geographic]

Kidwell CU*, Casallini JR*, Pradeep S, Scherer SD, Greiner D, Bayik D, Watson DC, Olson GS, Lathia JD, Johnson JS, Rutter J, Welm AL, Zangle TA, Roh-Johnson M: Transferred mitochondria accumulate reactive oxygen species, promoting proliferation. Elife. 2023. Mar 6;12:e85494. doi: 10.7554/eLife.85494.

Bayik D+, Bartels CF, Lovrenert K, Watson D, Zhang D, Kay K, Lauko A, Johnson S, Lo A, McGraw M, Grabowski M, Mohammadi AM, Veglia F, Fan Y, Vogelbaum MA, Scacheri P, Lathia J+: Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subset.  Cancer Res. 2022. Nov 15;82(22):4274-4287. +denotes co-corresponding author

Chambers LM*, Esakov EL*, Braley C, Trestan L, Alali Z, Bayik D, Lathia JD, Sangwan N, Bazeley P, Joehlin-Price AS, Dwidar M, Hajjar A, Ahern PP, Claesen J, Rose P, Vargas R, Michener C, Reizes O: Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy. Cancer Res. 2022. Oct 7;CAN-22-0455

Lauko A, Volovetz J, Turaga SM, Bayik D, Silver DJ, Mitchell K, Mulkearns-Hubert E, Watson DC, Desai K, Midha M, Hao J, McCortney K, Steffens A, Naik U, Ahluwalia MS, Bao S, Horbinski C, Yu J, Lathia J: SerpinB3 drives cancer stem cell survival in glioblastoma. Cell Rep. 2022. Sep 13;40(11):111348.

Lee J*, Bayik D*, Lathia JD: Pre-invasive to Invasive: PD-1 expressing macrophages shift lung cancer into high gear. Cancer Res. 2022. Jul 18;82(14):2515-2516 (commentary) * denotes equal contribution

Chandrasekharan UM, Kaur R, Harvey JE, Braley C, Rai V, Lee M, de Windt M, Hsieh J, Jaini R, Bayik D, Scheraga RG, Fernandez AP, DiCorleto PE, Husni ME: TNFR2 depletion reduces psoriatic inflammation in mice via downregulating specific dendritic cell populations in lymph nodes and inhibiting IL-23/IL-17 pathways. J. Invest. Dermatol. 2022. Aug 142 (8):2159-2172. PMCID: PMC9314460

 Bayik D*, Lee J*, Lathia JD: All glioblastoma are not equal: distinct spatial immune profiles between de novo and recurrent tumors. Cancer Immunol Res. 2022. Jul 1;10(7):787 (editorial) * denotes equal contribution

Watson DC, Johnson S, Santos A, Yin M, Bayik D, Lathia JD, Dwidar M: Scalable isolation and purification of extracellular vesicles from Escherichia coli and other bacteria. J. Vis. Exp. 2021. Oct 13. (176), e631552021. doi: 10.3791/63155. PMCID: PMC8729794

Bayik D, Lathia JD: Cancer stem cell-immune cell crosstalk in tumor progression. Nat Rev Cancer. 2021. Aug;21(8): 526-536. PMCID: PMC8740903 (perspective)

Otvos B*, Alban T*, Grabowski M, Bayik D, Mulkearns-Hubert E, Radivoyevitch T, Rabljenovic A, Johnson S, Androjna C, Mohammadi A, Barnett G, Ahluwalia A, Vogelbaum M, Fecci P, Lathia J: Preclinical modeling of surgery and steroids therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome. Clin Cancer Res. 2021. Apr 1;27(7):2038-2049. PMCID: PMC8026586 

Bayik D*, Lauko A*, Roversi GA, Serbinowski E, Acevedo-Moreno LA, Lanigan C, Orujov M, Lo A, Alban TJ, Kim A, Silver DJ, Nagy LE, Brown JM, Allende DS, Aucejo FN+, Lathia JD+: Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor cell myeloid profiles. Scientific Reports. 2020 Nov 2;10(1):18848. PMCID: PMC7606602 *denotes equal contribution; +denotes co-corresponding author

Bayik D*, Watson DC*, Lathia JD: Release the ballast: Glioblastoma rises above radiation therapy by exporting miR-603 in extracellular vesicles to become treatment-resistant. EBioMedicine. 2020. Jun;56:102788. PMCID: PMC7280744 *denotes equal contribution (commentary)

Bayyurt-Kocabas B, Almacioglu K, Alpdundar Bulut E, Gucluler G, Tincer G, Bayik D, Gursel M, Gursel I: Dual-adjuvant effect of pH-sensitive liposomes loaded with STING and TLR9 agonists regress tumor development by enhancing Th1 immune response. J Control Release. 2020. Sep (22)328:587-595.

Turaga S, Silver DJ, Bayik D, Paouri E, Peng S, Lauko A, Alban TJ, Borjini N, Stanko S, Naik U, Keri RA, Connor JR, Barnholtz-Sloan JS, Rubin JB, Berens M, Davalos D, Lathia JD:  JAM-A functions as a female microglial tumor suppressor in glioblastoma. Neuro Oncol.  2020. Nov 26;22(11):1591-1601. PMCID: PMC7690368

Alban TJ, Bayik D, Otvos B, Rabljenovic A, Leng L, Jia-shiun L, Roversi G, Lauko A, Momin A, Mohammadi AM, Peereboom DM, Ahluwalia MS, Matsuda K, Yun K, Bucala R+, Vogelbaum MA+, Lathia JD+: Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression. Frontiers in Immunol. 2020. Jun13:11:1191. PMCID: PMC7315581 +denotes co-corresponding author

Bayik D, Zhou Y, Park C, Hong C, Vail D, Silver DJ, Lauko A, Roversis GA, Watson DC, Lo A, Alban TJ, McGraw M, Sorensen MD, Grabowski MM, Otvos B, Vogelbaum MA, Horbinski CM, Kristensen BW, Khalil AM, Hwang TH, Ahluwalia MS, Chen F, Lathia JD: Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner. Cancer Discovery. 2020. Aug:10(8):1210-1225. PMCID: PMC7415660

Neumann CKA, Silver DJ, Venkaleshwari V, Zhang R, Traughber CA, Przybycin C, Bayik D, Smith JD, Lathia JD, Rini BI, Brown JM: MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma. Molecular Metabolism. 2020. 34: 136-145. PMCID: PMC7033598

Peereboom DM*, Alban TJ*, Grabowski MM, Alvarado AG, Otvos B, Bayik D, Roversi G, McGraw M, Huang P, Mohammadi AM, Kornblum HI, Radivoyevitch T, Ahluwalia MS, Vogelbaum MA+, Lathia JD+:  Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells. JCI Insight. 2019. Nov 14;4(22):e130748. PMCID: PMC6948860

Lauko A*, Bayik D*, Lathia J: IL-11 drives postsurgical hepatocellular carcinoma recurrence. EBioMedicine. 2019. 47:18-19. PMCID: PMC6796539 *denotes equal contribution (commentary)

Jimenez-Pascual A*, Hale JS*, Kordowski A, Pugh J, Silver DJ, Bayik D, Roversi G, Alban T, Rao S, Chen R, McIntyre TM, Colombo G, Taraboletti G, Holmberg KO, Forsberg-Nilsson K, Lathia JD+, Siebzehnrubl F+: ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells. Cancer Discovery. 2019. 9(11):1574-1589. PMCID: PMC7400732 *denotes equal contribution; +denotes co-corresponding author 

Horuluoglu B*, Bayik D*, Kayraklioglu N, Goguet E, Kaplan MJ, Klinman DM: PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus. J Autoimmun. 2019. 99: 24-32. PMCID: PMC6462249 *denotes equal contribution

Mulkearns-Hubert EE*, Torre-Healy LA*, Silver DJ, Eurich JT, Bayik D, Serbinowski E, Hitomi M, Zhou J, Przychodzen B, Zhang R, Sprowls S, Hale JS, Alban T, Berezovsky A, Bell BA, Lockman PR, Jha BK, Lathia JD: Development of a Cx46 targeting strategy for cancer stem cells. Cell Reports. 2019. 27 (4): P1062-1072.E5. PMCID: PMC6497083 *denotes equal contribution

Alban TJ, Alvarado AG, Sorensen MD, Bayik D, Volovetz J, Serbinowski E, Mulkearns-Hubert EE, Sinyuk M, Hale JS, Onzi GR, McGraw M, Huang P, Grabowski MM, Walthen CA, Ahluwalia MS, Radivoyevitch T, Kornblum HI, Kristensen BW, Vogelbaum MA+, Lathia JD+: Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis. JCI Insight. 2018. Nov 2; 3(21):e122264. PMCID: PMC6238746 +denotes co-corresponding author

Bayik D, Tross D, Klinman DM: Factors influencing the differentiation of human monocytic myeloid-derived suppressor cells into inflammatory macrophages. Frontiers in Immunol. 2018. 9(608) PMCID: PMC5879147

Bayik D, Tross D, Haile L, Verthelyi D, Klinman DM: Regulation of the maturation of human monocytes into immunosuppressive macrophages. Blood Adv. 2017. 1(26):2510-2519. PMCID: PMC5728638Watson DC, Bayik D, Srivatsan A, Bergamaschi C, Valentin A, Niu G, Bear J, Monninger M, Sun M, Morales-Kastresana A, Jones JC, Felber BK, Chen X, Gursel I, Pavlakis GN: Efficient production and enhanced tumor delivery of engineered extracellular vesicles. Biomaterials. 2016. 105:195-205. PMCID: PMC7156278

Bayik D, Gursel I, Klinman DM: Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides. Pharmaco Res. 2016. 105:216-25. PMCID: PMC6417099 (review).

Wang J*, Shirota Y*, Bayik D, Shirota H, Tross D, Gulley JL, Wood L, Berzofsky JA, Klinman DM: Effect of TLR agonists on the differentiation and function of human monocytic myeloid derived suppressor cells. J Immunol. 2015.194(9):4215-21 PMCID: PMC4402268 *denotes equal contribution

Telkoparan P, Erkek S, Yaman E, Alotaibi H, Bayik D, Tazebay UH: Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that is involved in cytokinetic abscission, and it connects cell division to Rap2 signaling. PloS One. 2013. 9;8(7):e69289. PMCID: PMC3716640